Be prepared to treat patient for shock as well as hemorrhage. Continue for at least 2≣ h after each dose, or longerĪs dictated by patient's condition. Monitor BP and pulse q15≣0min, or more often if indicated.Do not use protamine if only minor bleeding occurs during heparin therapy because withdrawal of heparin will usually correct.InteractionsNo clinically significant interactions established. Hematologic: Protamine overdose or "heparin rebound" (hyperheparinemia). Body as a Whole: Urticaria, angioedema, pulmonary edema, anaphylaxis, dyspnea, lassitude transient flushing and feeling of warmth. Solutions are stable for 72 h at this temperature.Īdverse Effects ( 1%) CV: Abrupt drop in BP (with rapid IV infusion), bradycardia. Store protamine sulfate injection at 2°≨° C (36°≤6° F) protamine powder for injection and.INCOMPATIBILITIES Solution/additive: radiocontrast materials. Give over 2≣ h or longer as determined by coagulation studies. NEVER give more than 50 mg in any 10 min period or 100 mg in any 2 h period. Continuous: Further dilute in 50 mL or more of NS or D5W.ĪDMINISTER: Direct: Give each 50 mg or fraction thereof slowly over 10≡5 min. PREPARE: Direct: Reconstitute each 50 mg with 5 mL of sterile water for injection. Note: Verify correct IV concentration and rate of infusion for infants or children with physician. Note: Titrate dose carefully to prevent excess anticoagulation because protamine has a longer half-life than heparin and also has Route & Dosage Antidote for Heparin OverdoseĪdult/ Child: IV 1 mg for every 100 units of heparin to be neutralized (max: 100 mg in a 2 h period), give the first 25≥0 mg by slow Cautious UseĬardiovascular disease history of allergy to fish vasectomized or infertile males lactation patients who have received Hemorrhage not induced by heparin overdosage pregnancy (category C). Unlabeled UsesĪntidote for heparin administration during extracorporeal circulation. Anticoagulantīecause protamine is strongly basic, it combines with strongly acidic heparin to produce a stable complex thus anticoagulantĪntidote for heparin calcium or heparin sodium overdosage (after heparin has been discontinued). Purified mixture of simple, low-molecular-weight proteins obtained from sperm or testes of suitable fish species.